Role of Blood Pressure in the Progression of Microalbuminuria in Elderly Japanese Type 2 Diabetic Patients: A 7-Year Follow-up Study

Abstract

This 7-year retrospective longitudinal study was carried out in order to clarify the clinical features of elderly type 2 diabetic patients with microalbuminuria. Elderly Japanese type 2 diabetic patients ( n = 22; age 50–73 years) with microalbuminuria were studied retrospectively. Patients whose urinary albumin excretion rate (UAER) decreased over 7 years were considered ‘non-progressors' ( n = 8) whereas those whose UAER increased were considered ‘progressors' ( n = 14). The mean 7-year level of glycosylated haemoglobin (HbA1c) did not differ significantly between non-progressors and progressors but the mean 7-year blood pressure (BP) of progressors (101 ± 8 mmHg) was significantly higher than that of non-progressors (92 ± 7 mmHg). In progressors who received no anti-hypertensive drugs, systolic BP was above the BP goal of 130/85 mmHg but mean BP and diastolic BP were below this goal. The results are consistent with the view that hypertension affects the progression of microalbuminuria; raised systolic BP may be a factor in this progression in elderly type 2 diabetic patients.