Dose-Dependent Effect of an Oral Adsorbent, AST-120, in Patients with Early Chronic Renal Failure

Author:

Yorioka N1,Ito T1,Masaki T1,Ogata S1,Asakimori Y1,Tanji C1,Kyuden Y1,Komiya Y2,Kumagai J2,Taniguchi Y3,Kohno N1

Affiliation:

1. Department of Molecular and Internal Medicine, Hiroshima University, Hiroshima, Japan

2. Department of Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

3. Division of Blood Purification, Hiroshima University Hospital, Hiroshima, Japan

Abstract

We evaluated the dose dependence of an oral adsorbent, AST-120, in 31 patients with early chronic renal failure (baseline serum creatinine: 1.2–3.0 mg/dl). Twenty-three patients were given AST-120 and eight patients were not. AST-120 was administered at three different maintenance doses, < 3.0 g, 3.0 g and 6.0 g/day, according to patients' ability to tolerate treatment. The treatment period was 12 months. The slope of the reciprocal of serum-creatinine concentration versus time was calculated to assess the progression of renal failure. This slope became significantly less steep after AST-120 treatment at 6.0 g/day, but did not change significantly at the other doses. These findings suggest that 6.0 g/day of AST-120 may delay the initiation of dialysis in patients with early chronic renal failure.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

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