The Impact of Acute Dynamic Exercise on Intraocular Pressure: Role of the β2-Adrenergic Receptor Polymorphism

Author:

Güngör K1,Beydaăi H2,Bekir N1,Arslan C3,Süer C4,Erbağci İ1,Ergenoğlu T2,Aynacioğlu AŞ5

Affiliation:

1. Medical Faculty, Department of Ophthalmology, Gaziantep University, Gaziantep, Turkey

2. Medical Faculty, Department of Physiology, Mersin University, Mersin, Turkey

3. Physical Education and Sports School, Gaziantep University, Gaziantep, Turkey

4. Medical Faculty, Department of Physiology, Erciyes University, Kayseri, Turkey

5. Medical Faculty, Department of Pharmacology, Pamukkale University, Denizli, Turkey

Abstract

Effects of mutations in the β2-adrenergic receptor (β2AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 ± 2.8 years). Intraocular pressures were measured pre- and post-exercise. Weight, height, body mass index, and maximal oxygen (VO2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the β2AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. β2AR stimulation during exercise could be an important regulator of IOP response and determining β2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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