Effect of Lipo-PGE1 on Health-related Quality of Life in Patients with Systemic Sclerosis and Systemic Lupus Erythematosus in Japan

Author:

Hoshi K1,Fukuhara S2

Affiliation:

1. Institute of Medical Science, St Marianna University School of Medicine, Kanagawa, Japan

2. Department of Epidemiology and Healthcare Research, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Abstract

We investigated the effect of Lipo-PGE1, a prostaglandin (PG) E1 preparation used to treat cutaneous ulcers associated with systemic sclerosis (SS) and systemic lupus erythematosus (SLE), on health-related quality of life (HR-QOL) using the Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire. A total of 192 SS and SLE patients were treated for 3 months. At baseline the scores for each of the five SF-36 subscales were significantly lower than the age- and sex-adjusted standard values for the Japanese general population. After treatment, mean (± SD) SF-36 scores for body pain and general health perception significantly increased from 48.6 ± 24.1 to 55.3 ± 26.1 and from 36.8 ± 16.7 to 40.2 ± 17, respectively. Emotional QOL parameters including vitality and mental health, however, showed no improvement. Physician-rated symptom scores significantly improved after administration of Lipo-PGE1. In conclusion, Lipo-PGE1 improved both cutaneous ulcers and HR-QOL, especially physical QOL.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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