Anti-Pituitary Antibody-Induced Multiple Endocrine Disorders in Mice

Author:

Koike H1,Kanda T2,Motooka M2,Tamura J3,Kobayashi I1

Affiliation:

1. Department of Laboratory Medicine, Gunma University School of Medicine

2. Department of General Medicine, Gunma University School of Medicine

3. Department of Laboratory Sciences School of Health Sciences, Gunma University School of Health Sciences, Maebashi, Gunma, Japan

Abstract

Circulating anti-pituitary antibodies (APAs) have been detected in patients with autoimmune diseases, although the role of autoantibodies in the pathogenesis of autoimmune diseases is still unclear. With the aim of elucidating the autoimmune mechanisms involved in patients with multiple endocrine disorders, we evaluated the pathological changes in the pituitary gland, thyroid, pancreas and adrenal gland of mice, both wild-type and using a murine model of autoimmune thyroid disease [MRL-lpr/lpr] that had been immunized with murine, rat, porcine or human pituitary glands. In four of seven mice, a 22 kD band corresponding to APA was detected by Western blotting in the serum from mice that had been immunized with human pituitary tissues but not in the serum from mice immunized with rat or pig tissue. Inflammatory changes were detected in all groups of mice, occurring in the hypophysis, pancreas and adrenal glands but not in the thyroid. In conclusion, APA-induced autoimmune endocrine disorders are likely to be important for studying the mechanisms involved in autoimmune syndromes.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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