Serum Prostate-Specific Antigen Determination in Prostatic Carcinoma-Reference-Cited by-同舟云学术

Serum Prostate-Specific Antigen Determination in Prostatic Carcinoma

Published:1987-09 Issue:3 Volume:2 Page:184-186
ISSN:1724-6008
Container-title:The International Journal of Biological Markers
language:en
Short-container-title:Int J Biol Markers

Author:

Tizzani Alessandro¹,Casetta Giovanni¹,Piana Paolo¹,Bellina Maurizio¹,Pecchio Ferdinando²,Aimo Giuseppe²,Adamo Rita²

Affiliation:

1. Institute of Nephro-Urology University of Torino

2. Laboratories “Baldi e Riberi” Hospital San Giovanni Battista, Molinette, Torino - Italy

Abstract

Prostate-specific antigen (PSA) is a tissue-specific glycoprotein identified by Wang in 1979. It is synthesized in the prostate independently of prostatic acid phosphatase (PAP). A total of 199 subjects were divided into four groups: controls aged less than 50 years, controls aged more than 50 years, patients with benign prostatic hyperplasia (BPH) and patients with prostatic carcinoma. PSA cut-off value was set at 10 ng/ml (mean for the BPH group plus 2 SD). With this cut-off value PSA could not be used as an early predictor of prostatic carcinoma. The association of PSA and PAP in prostatic cancer increases the number of patients with positive biological markers.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/172460088700200309

Reference11 articles.

1. Measurement of prostate-specific antigen by radioimmunoassay.

2. Biological Markers in Prostate Cancer

3. An Evaluation of the Immunochemical Measurement of Prostatic Acid Phosphatase and Prostatic Specific Antigen in Carcinoma of the Prostate

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