Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma

Author:

Zhang Heng1,Liao Yusheng1,Zhang Hongfeng2,Wu Jie1,Zheng Dan1,Chen Zhitao1ORCID

Affiliation:

1. Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province; Key Laboratory for Molecular Diagnosis of Hubei Province, Wuhan, China

2. Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Abstract

Objective: This study aimed to investigate the correlation of Helicobacter pylori (Hp) infection with disease risk and severity of colorectal adenoma, also to explore the association of cytotoxin-associated gene A (CagA) positive (CagA+)- Hp infection with gastrin and ki-67 expressions in colorectal adenoma patients. Methods: There were 1000 colorectal adenoma patients and 1500 controls consecutively enrolled, then Hp infection status was determined by 14C urea breath test and rapid urease test. Also, serum CagA expression and gastrin expression of colorectal adenoma patients were determined by enzyme-linked immunosorbent assay. Ki-67 expression in adenoma tissue of colorectal adenoma patients was assessed using immunohistochemistry. Results: Hp+ rate in colorectal adenoma patients (623 (62.3%)) was more elevated than that in controls (814 (54.3%)). Multivariate logistic regression model analysis disclosed that Hp+ was an independent risk factor for colorectal adenoma. Additionally, Hp+ was positively associated with tumor size and high-grade intraepithelial neoplasia in colorectal adenoma patients. Also, serum gastrin expression and intratumoral ki-67 expression were higher in Hp+ CagA+ patients and Hp+ CagA patients compared to Hp patients, and they were also higher in Hp+ CagA+ patients compared to Hp+ CagA patients. Conclusion: Hp infection positively associates with higher disease risk and worse disease conditions of colorectal adenoma, and CagA enhances the carcinogenicity of Hp in colorectal adenoma.

Funder

specialized research fund for the doctoral program of higher education of china

Wuhan City Health Bureau project

Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

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