Is Adjuvant Tamoxifen Recommended in Post-Menopausal Node-Negative Breast Cancer Patients with High Estrogen Receptor Values?-Reference-Cited by-同舟云学术

Is Adjuvant Tamoxifen Recommended in Post-Menopausal Node-Negative Breast Cancer Patients with High Estrogen Receptor Values?

Published:2000-04 Issue:2 Volume:15 Page:135-138
ISSN:1724-6008
Container-title:The International Journal of Biological Markers
language:en
Short-container-title:Int J Biol Markers

Author:

Floiras J.-L.¹,Hacene K.²,Turpin F.³,Spyratos F.⁴

Affiliation:

1. Department of Radiotherapy, Centre René Huguenin, St-Cloud - France

2. Department of Medical Statistics, Centre René Huguenin, St-Cloud - France

3. Department of Medicine, Centre René Huguenin, St-Cloud - France

4. Oncobiology Laboratory, Centre René Huguenin, St-Cloud - France

Abstract

The impact of ER levels on the response to tamoxifen was evaluated in 1,623 postmenopausal primary breast cancer patients treated at our center (median follow-up 8.2 years). In patients receiving adjuvant tamoxifen a significantly longer disease-free survival (DFS) was observed when ER levels were elevated (p<0.00001). Very high ER (>424 fmol/mg protein) appeared to be detrimental in node-negative patients not treated with tamoxifen.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/172460080001500202

Reference7 articles.

1. Oestrogen receptors and breast cancer

2. Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer

3. Short recurrence-free survival associated with high oestrogen receptor levels in the natural history of postmenopausal, primary breast cancer

4. Is the negative prognostic value of high oestrogen receptor (ER) levels in postmenopausal breast cancer patients due to a modified ER gene product?

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