Detection of a Soluble form of the Receptor for Interleukin 2 in the Serum of Patients with Hairy Cell Leukaemia-Reference-Cited by-同舟云学术

Detection of a Soluble form of the Receptor for Interleukin 2 in the Serum of Patients with Hairy Cell Leukaemia

Published:1986-05 Issue:2 Volume:1 Page:101-104
ISSN:1724-6008
Container-title:The International Journal of Biological Markers
language:en
Short-container-title:Int J Biol Markers

Author:

Chilosi Marco¹,Pizzolo Giovanni²,Semenzato Gianpietro¹,Cetto Gian Luigi¹

Affiliation:

1. Istituto di Anatomia Patologica, Università di Verona, Istituto di Medicina Clinica Università di Padova, Italy

2. Cattedra di Ematologia, Università di Verona, Istituto di Medicina Clinica Università di Padova, Italy

Abstract

The sera of patients with hairy cell leukaemia (HCL) contain a factor which inhibits the binding of anti-IL-2R antibody to its target (activated T lymphocytes). The presence of this factor, which probably corresponds to the soluble form of IL-2R (sIL-2R), can be easily detected using a simple immunocytochemical inhibition assay. In a series of patients with chronic lymphoproliferative diseases the presence of sIL-2R appeared to be specific for HCL, using the sensitivity of our test, since it could not be detected in sera from normal subjects and patients with B-cell lymphocytic leukaemia or Hodgkin's disease. Thus it might be used as an additional tool for characterizing HCL patients.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/172460088600100208

Reference11 articles.

1. Leukemic reticuloendotheliosis (hairy cell leukemia)

2. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

3. Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: The use of cryostat sections

4. Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia

5. Alpha-interferon activates the natural killer system in patients with hairy cell leukemia

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