Cytofluorimetric Evaluation of DNA Ploidy in Lung Cancer: A Bronchoscopic Study-Reference-Cited by-同舟云学术

Cytofluorimetric Evaluation of DNA Ploidy in Lung Cancer: A Bronchoscopic Study

Published:2005-04 Issue:2 Volume:20 Page:87-92
ISSN:1724-6008
Container-title:The International Journal of Biological Markers
language:en
Short-container-title:Int J Biol Markers

Author:

Oliani C.¹,Barana D.¹,Cazzadori A.²,Zanolin E.³,Santo A.¹,Pasini F.¹,Padovani M.¹,Mazzini G.⁴,Cetto G.L.¹

Affiliation:

1. Institute of Medical Oncology, Azienda Ospedaliera and University of Verona

2. Department of Pneumology, Azienda Ospedaliera, Verona

3. Institute of Statistics, University of Verona

4. Center of Histochemistry CNR, Pavia - Italy

Abstract

The study of the biological characteristics of lung cancer is gaining more and more interest both because of their potential role as prognostic indicators and for therapeutic reasons. The DNA content estimated by flow cytometry in surgical samples of non-small cell lung cancer (NSCLC) has already been demonstrated to be correlated with survival in these patients. From July 1990 to February 1992 we analyzed the DNA distribution of bronchoscopic biopsies from 88 patients with lung cancer (18 small cell lung cancer, SCLC, and 68 NSCLC, two unspecified histology). Twenty-eight tumors (34.6%) had a diploid DNA distribution, while 53 were aneuploid (65.4%). A correlation was found between DNA ploidy and survival. Evaluation of the DNA content in bronchoscopic samples in a large series of patients could determine the role of this analysis prior to surgery in NSCLC and its value as a marker with respect to prognosis and response to therapy in SCLC.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/172460080502000202

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