CD30/CD30 Ligand and CD40/CD40 Ligand in Malignant Lymphoid Disorders

Author:

Younes A.1,Carbone A.2

Affiliation:

1. Department of Lymphoma, U.T. M.D. Anderson Cancer Center, Houston, Texas - U.S.A.

2. Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano - Italy

Abstract

CD30 and CD40 are members of the tumor necrosis factor (TNF) receptor family. These two receptors have pleiotropic biologic functions including induction of apoptosis and enhancing cell survival. This review will discuss the pattern of expression of these receptors in malignant lymphoid disorders and their prospective ligands. Understanding issues related to these two ligands and their receptors in lymphoid malignancies may help to improve the classification of these diseases and could open the doors for new treatment strategies.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

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