Intraluminal Application of Fibrinogen Adhesive by the Example of the Endarterectomised Pig Aorta

Abstract

The gluing of tissue with highly concentrated fibrinogen, designated in the following briefly as fibrin gluing, is a relatively old technique. Bergel already reported in 1909 on first trials of hemostasis with fibrin powder.1 In 1915, Grey used a fibrin solution prepared from sheep blood for hemostasis in intracranial operations.2 In 1944, Cronkite fixed skin transplants with a fibrinogen-thrombin mixture. Difficulties occurred with the adhesivity, probably in consequence of low fibrinogen concentrations.3 Since the ex perimental and clinical investigations of Spängler et al.,4,3 a large number of possible applications of fibrin gluing has been described.6-12