ATP, Creatine Phosphate and Glycogen Content in Human Myocardial Biopsies: Markers for the Efficacy of Cardioprotection During Aorto-Coronary Bypass Surgery-Reference-Cited by-同舟云学术

ATP, Creatine Phosphate and Glycogen Content in Human Myocardial Biopsies: Markers for the Efficacy of Cardioprotection During Aorto-Coronary Bypass Surgery

Published:1984-05 Issue:3 Volume:18 Page:127-134
ISSN:0042-2835
Container-title:Vascular Surgery
language:en
Short-container-title:Vascular Surgery

Author:

van der Vusse Ger J.¹,Coumans Will A.¹,van der Veen Erik¹,Drake Angela J.²,Flameng Willem³,Suy Raf³

Affiliation:

1. Department of Physiology, Biomedical Center, University of Limburg, Maastricht, The Netherlands

2. Midhurst Medical Research Institute, Midhurst, England

3. Department of Cardiovascular Surgery, St. Rafael Clinics, Leuven, Belgium

Abstract

Measurements of the myocardial content of ATP, creatine phosphate and glycogen provide a sensitive marker of the effect of inevitably global ischemia on myocardial tissue during aorto-coronary bypass surgery and give insight in the efficacy of various cardioprotective techniques. Continuous aortic cross clamping for performance of the distal anastomoses with multidose St. Thomas cardioplegia did not result in significant changes in the myocardial ATP, creatine phosphate and glycogen content. In contrast, hypothermic intermittent crossclamping resulted in a significant reduced tissue content of these markers of myocardial ischemia.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/153857448401800301

Reference13 articles.

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2. Myocardial preservation

3. Cardioplegic arrest in pigs

4. A Comparison of Intermittent and Continuous Arrest for Prolonged Hypothermic Cardioplegia

5. The additive protective effects of hypothermia and chemical cardioplegia during ischemic cardiac arrest in the rat

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