Incomplete Hemisphere Ischemic Model in the Dog Produced by Electrocoagulating Several Major Intracranial Arteries

Abstract

An obstacle in stroke research is lack of a suitable animal model; therefore, there is an apparent need for an experimental model of ischemia that resembles as closely as possible what is observed in human beings. The authors used soma tosensory evoked potentials (SEPs) and histologic examination to evaluate the practicability and reliability of an incomplete ischemic model of the brain in dog after observing the circle of Willis of dog. Incomplete cerebral hemisphere is chemia was produced by electrocoagulating various vessels from the circle of Willis. After occlusion, there was a precipitous decrease in the amplitude of cerebral cortical components. The majority of neurons at the sixth hour after occlusion became swollen and some were shrunken. This study shows that the model is a useful one that has the advantages of high rates of successful ischemia and prediction of its size and location, and it is suitable for intracranial microvasosurgical and pathophysiological research in cerebral ischemia.