Oxygenated Perfluorocarbons Protect the Intestine From the Ischemia/Reperfusion Injury in Rabbits-Reference-Cited by-同舟云学术

Oxygenated Perfluorocarbons Protect the Intestine From the Ischemia/Reperfusion Injury in Rabbits

Published:2011-05-13 Issue:5 Volume:45 Page:426-432
ISSN:1538-5744
Container-title:Vascular and Endovascular Surgery
language:en
Short-container-title:Vasc Endovascular Surg

Author:

Ntinas Achilleas¹,Vrochides Dionisios²,Iliadis Stavros³,Papageorgiou Georgios³,Alvanou-Achparaki Athanasia⁴,Papadimitriou Dimitrios⁵,Spiridis Charalambos⁶,Gerasimidis Thomas⁶

Affiliation:

1. 5th Department of Surgery, “Hippokration” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece,

2. Department of Surgery, Multi Organ Transplant Program, Mc Gill University, Montreal, Canada

3. Aristotle University of Thessaloniki, Biological Chemistry, Thessaloniki, Greece

4. Laboratory of Histology and Embryology, Aristotle University of Thessaloniki, Thessaloniki, Greece

5. 2nd Surgical Department, Division of Vascular Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece

6. 5th Department of Surgery, “Hippokration” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

Objective: To investigate whether intraluminal administration of oxygenated perfluorocarbons (PFCs) protects the enterocyte from acute ischemia-reperfusion (I/R) injury. Materials and Methods: Twenty rabbits were divided in 4 groups: sham-operated controls (group A), acute I/R (group B), acute I/R plus infusion of oxygenated PFCs 30 minutes before ischemia (group C), and acute I/R plus infusion of oxygenated PFCs 30 minutes before reperfusion (group D). Serum creatine phosphokinase (CPK) and mucosal disaccharidase activity were examined. Intestinal biopsies were obtained for electron microscopy study. Results: Group B CPK mean values are 3495.2 ± 157.35 and 4855 ± 350.21 U/L. Group C: 2674.6 ± 265.87 and 3231 ± 232.30. Group D: 2382.2 ± 102.90 and 3217.6 ± 185.61 at 120 and 180 minutes (P < .05). At 180 minutes, maltase and sucrose values were 33.63, 51.88, 8.45, and 19.91, and 17.99, 22.87, 6.62, and 14.24 µmol/min per g for groups A, B, C, and D, respectively (P < .05). Histopathology showed the least cellular deterioration in PFC groups. Conclusion: Oxygenated PFCs protect the enterocyte during bowel I/R.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,General Medicine,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/1538574411402223

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