Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone-Reference-Cited by-同舟云学术

Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone

Published:2013-05-15 Issue:6 Volume:28 Page:954-962
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Akagi Hiroyuki¹,Iwata Munetaka¹,Ichinohe Tomu¹,Amimoto Hirokazu¹,Hayashi Yuuta¹,Kannno Nobuo¹,Ochi Hiroki²,Fujita Yukihiro³,Harada Yasuji¹,Tagawa Masahiro¹,Hara Yasushi¹

Affiliation:

1. Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan

2. Division of Veterinary Microbiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan

3. Laboratory of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Chuou-ku, Sagamihara, Japan

Abstract

Hydroxyapatite (HA)/poly-l-lactide(PLLA) composite biomaterials are available for orthopedic applications, but bioresorption and cell-mediated inflammation in bone cortex are unknown. We conducted an 84-month follow-up study with Beagle dogs that were subjected to implants with either PLLA (left femur) or HA/PLLA (right femur). Histological and radiographic analysis showed that HA/PLLA screws induced significant increases in HA content from 36 months onward and complete burr hole closure at 60 months, whereas PLLA screws did not. Moreover, PLLA screws induced more severe fibrous tissue and histiocyte infiltration. HA/PLLA screws promote earlier burr hole replacement and have superior biocompatibility compared to PLLA screws.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885328213487754

Reference20 articles.

1. Bioabsorbable fixation in orthopaedic surgery and traumatology

2. Single Absorbable Polydioxanone Pin Fixation for Distal Chevron Bunion Osteotomies

3. Absorbable pins of self-reinforced poly-L-lactic acid for fixation of fractures and osteotomies

4. Activation of the complement system and adverse effects of biodegradable pins of poly-lactic acid (Biofix®) in osteochondritis dissecans

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications;Journal of Composites Science;2024-06-08

2. Fixation devices made of poly-L-lactide composite for rib reconstruction after thoracotomy;Journal of Cardiothoracic Surgery;2024-03-15

3. The Potential for Foreign Body Reaction of Implanted Poly-L-Lactic Acid: A Systematic Review;Polymers;2024-03-14

4. Treatment of patellar fractures using bioresorbable forged composites of raw particulate unsintered hydroxyapatite/poly-L-lactide cannulated screws and nonabsorbable sutures;Injury;2021-06

5. Strontium-incorporated mineralized PLLA nanofibrous membranes for promoting bone defect repair;Colloids and Surfaces B: Biointerfaces;2019-07