Synthesis and biocompatibility properties of polyester containing various diacid based on isosorbide

Abstract

Biocompatible polyesters were prepared from isosorbide, various aliphatic diacid via a simple non-solvent polycondensation with a low toxicity catalyst. The successful synthesis of the polyesters was confirmed by gel permeation chromatography, 1H-nuclear magnetic resonance and Fourier transform infrared spectroscopes, and differential scanning calorimetry. The degradation tests were performed at 37°C in phosphate buffer solution (approximately pH 7.3). The in vitro cytocompatibility test results following culture of osteoblasts on the polymer surface showed that relative cell number on poly(isosorbide sebacate) and poly(isosorbide adipate) films after 5 days of culture on polymer films proliferated at least as well as those on a culture plate.