Development of a Ceramic Heart Valve-Reference-Cited by-同舟云学术

Development of a Ceramic Heart Valve

Published:1989-07 Issue:1 Volume:4 Page:33-55
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Mitamura Yoshinori¹,Hosooka Koji¹,Matsumoto Takeo¹,Otaki Kenji²,Sakai Keisuke²,Tanabe Tatsuzo²,Yuta Toshio³,Mikami Tomohisa³

Affiliation:

1. Research Institute of Applied Electricity Hokkaido University Sapporo 060, Japan

2. Second Department of Surgery School of Medicine Hokkaido University Sapporo 060, Japan

3. Department of Biomedical Engineering Graduate School of Engineering Hokkaido University Sapporo 060, Japan

Abstract

A durable and thromboresistant ceramic heart valve comprised of a single crystal alumina disk and titanium nitride (TiN) valve ring has been developed. Blood compatiblity was examined by scanning electron microscopy (SEM) examinations of the valves implanted in sheep for 35 (#1), 26 (#2), 20 (#3), 23 (#4), and 26 (#5) days. The single crystal alumina and TiN surfaces were free of platelet aggregation or fibrin networks, except for some depositions of fibrin and platelets on the outflow TiN ring in #3, and isolated red cells on the outflow TiN ring in #5. Durability testing under high pressure (1750 mmHg = 233 KPa) pulsatile conditions showed that the safety factor of the ceramic valve was more than seven times greater than anticipated. The ceramic valve is promising as an artificial heart valve.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/088532828900400103

Reference27 articles.

1. Fracture and embolization of a Björk-Shiley disc

2. Strut fracture of the Björk-Shiley aortic valve

3. Entrapment of both leaflets of St. Jude Medical aortic valve prosthesis in a child

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