Blood Compatible Phospholipid-Containing Polyurethanes: Synthesis, Characterization and Blood Compatibility Evaluation

Abstract

A new diol, bis[2-(2-hydroxyethyldimethylammonio)ethyl]butylenediphosphate, that contains two phosphatidylcholine analogous moieties in one diol molecule, was synthesized and characterized. The diol together with 1,4-butanediol as chain extender was further incorporated into the propolymer of poly(ethylene oxide) (Mn = 1000, 2000,6000) and 4,4'-methylenediphenyl diisocyanate. The resulting phospholipid poly(ether urethane)s show viscosity behavior of common polyelectrolytes. The bulk and surface characteristics of the new phospholipid poly(ether urethane)s were investigated by IR, GPC, ATR-FTIR, ESCA and contact angle measurements. The new polymers possessed relatively hydrophilic surface revealed by contact angle measurements. The blood compatibilities of the polyurethanes were evaluated by platelet rich plasma contacting studies and scanning electron microscopy observation using medical grade PVC as the reference. No platelet adhesion was observed for all new phospholipid polyurethane casting films. This new type of phospholipid polyurethane is expected to have potential biomedical applications.