Bioactive Polymers 68-Controlled Release of Neomycine-Furazolidone Bicomponent System from Xanthan Hydrogel-Reference-Cited by-同舟云学术

Bioactive Polymers 68-Controlled Release of Neomycine-Furazolidone Bicomponent System from Xanthan Hydrogel

Published:1993-01 Issue:3 Volume:7 Page:265-276
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Dumitriu Severian¹,Popa Marcel I.¹,Dumitriu Maria¹,Dumitriu Daniela²,Tara Alina³

Affiliation:

1. Polytechnic Institute of Jassy Department of Macromolecular Chemistry Jassy, Bul. Copou, 11, R-6600 Jassy, Romania

2. C. R. I. S. M. A. Interdisciplinary Research Center for Advanced Medical Systems University of Siena Le Scotte, Siena, Italy

3. Polytechnic Institute of Bucharest Faculty of Chemical Engineering Bucharest, Romania

Abstract

The neomycine-furazolidone-xanthan complex has been synthesized. Neomycine is covalently linked to xanthan, while furazolidone is inserted in the hydrogel formed by the reaction between neomycine and xanthan. The content of neomycine and furazolidone depends on the drug rate in the reaction medium. Thus, a zero-order kinetics is obtained for the release of both neomycine and furazolidone in basic medium. The complex's antimicrobial activity is intensified.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/088532829300700305

Reference20 articles.

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