A Clinical Report of Bone Regeneration in Maxillofacial Surgery using Bonelike ® Synthetic Bone Graft

Abstract

The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike® graft in repairing surgical cystic bone defects. Bonelike® is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocols, radiological examinations are performed and Bonelike®/bone retrieved samples have been analyzed histologically using non-decalcified sections obtained perpendicular to bone length axis. Radiographic examination and histological results clearly demonstrate an extensive new bone formation apposed on Bonelike® granules with a significant degree of maturation. These clinical applications in maxillary bone defects indicate perfect bone bonding between new bone formed and Bonelike ® granules, along with partial surface biodegradation. This quick and effective osteoconductive response from Bonelike® may reduce the time needed to reconstruct the bone defected area of patients.