Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents-Reference-Cited by-同舟云学术

Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents

Published:2008-11-25 Issue:4 Volume:24 Page:353-383
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Silvestri D.¹,Cristallini C.²,Gagliardi M.³,Barbani N.³,D'Acunto M.³,Ciardelli G.⁴,Giusti P.⁵

Affiliation:

1. Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, , Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis'Nicolino Marchetti' (C.I.B.E.), Pisa, Italy

2. CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy

3. Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy

4. Department of Mechanics, Politecnico in Turin, Italy

5. Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy, Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis

Abstract

The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885328208095198

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