Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair

Author:

Smith Matthew J1,Dempsey Sandi G1,Veale Robert WF1,Duston-Fursman Claudia G1,Rayner Chloe A F1,Javanapong Chettha1,Gerneke Dane2,Dowling Shane G1,Bosque Brandon A1,Karnik Tanvi1,Jerram Michael J1,Nagarajan Arun1,Rajam Ravinder1,Jowsey Alister1,Cutajar Samuel1,Mason Isaac1,Stanley Roderick G1,Campbell Andrew1,Malmstrom Jenny3,Miller Chris H1,May Barnaby C H1ORCID

Affiliation:

1. Department of Research and Clinical Development, Aroa Biosurgery Limited, Auckland, New Zealand

2. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

3. Department of Chemical and Materials Engineering, The University of Auckland, Auckland, New Zealand

Abstract

Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties.

Funder

Aroa Biosurgery

Callaghan Innovation

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

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