Immunological Study of a Chitosan Prosthesis in the Sciatic Nerve Regeneration of the Axotomized Dog-Reference-Cited by-同舟云学术

Immunological Study of a Chitosan Prosthesis in the Sciatic Nerve Regeneration of the Axotomized Dog

Published:2003-07 Issue:1 Volume:18 Page:15-23
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Rosales-Cortés M.¹,Peregrina-Sandoval J.¹,Bañuelos-Pineda J.¹,Sarabia-Estrada R.¹,Gómez-Rodiles C. C.¹,Albarrán-Rodríguez E.¹,Zaitseva G. P.²,Pita-López M. L.²

Affiliation:

1. Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

2. Div. Ciencias Biológicas y Ambientales Dpto. Biología Celular y Molecular C.U.C.B.A. UdeG, Mexico

Abstract

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885328203018001002

Reference26 articles.

1. 1. Gómez-Pinedo, U., López-Dellamary, F., Mora-Galindo, J., Bañuelos-Pineda, J., Chávez-Delgado, E., Macias-Islas, M., Martinez-Contreras, A., González-Pérez, O., Garzón, P., Luquín, S., Navarro-Ruiz, A. and García-Estrada, J. (2001). Utilización de prótesis de quitosana y silicona en la regeneracion del nervio ciatico axotomizado de ratas , Archivos Neurociencias. Mexico, 6(4): 184-193 .

2. 2. Chavéz-Delgado, E. (2001). Chitosan prótesis nerviosas y vehículo de esteroides en la regeneración del nervio facial de conejo, Análisis Ultraestructural . An, ORL-Mex. 46(4): 128-139 .

3. 3. Rosales-Cortés, M. (2000). Uso de chitosan y neuroesteroides en la regeneración del nervio ciático del perro, S. Cientia , C:UC:C:B:A. 2: 19-25 .

4. Chitosan-mediated stimulation of macrophage function

5. 5. Dornish, M. (2001). Standards and Guidelines for Biopolymers in Tissue-engineered Medical Products: ASTM Alginate and Chitosan Standard Guides, American Society for Testing and Materials , Annals of the New York Academy of Sciences, 944: 388-397 .

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective;MedComm – Biomaterials and Applications;2024-02-03

2. Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries;Carbohydrate Polymers;2023-09

3. Naturally occurring biological macromolecules-based hydrogels: Potential biomaterials for peripheral nerve regeneration;International Journal of Biological Macromolecules;2020-07

4. The electrostimulation and scar inhibition effect of chitosan/oxidized hydroxyethyl cellulose/reduced graphene oxide/asiaticoside liposome based hydrogel on peripheral nerve regeneration in vitro;Materials Science and Engineering: C;2020-04

5. Chitosan conduit combined with hyaluronic acid prevent sciatic nerve scar in a rat model of peripheral nerve crush injury;Molecular Medicine Reports;2018-01-08