Novel Polymeric Coatings with the Potential to Control In-stent Restenosis — An In Vitro Study-Reference-Cited by-同舟云学术

Novel Polymeric Coatings with the Potential to Control In-stent Restenosis — An In Vitro Study

Published:2008-11-25 Issue:5 Volume:24 Page:437-452
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Nickson C. M.¹,Doherty P. J.²,Williams R. L.²

Affiliation:

1. Clinical Engineering, School of Clinical Sciences, University of Liverpool Duncan Building, Daulby Street, Liverpool, L69 3GA,

2. Clinical Engineering, School of Clinical Sciences, University of Liverpool Duncan Building, Daulby Street, Liverpool, L69 3GA

Abstract

Restenosis following percutaneous coronary intervention (PCI) is a considerable problem in long-term performance of cardiovascular stents, with a functional endothelial cell monolayer being important in its prevention. This study evaluates the influence of polymer coatings on human aortic endothelial cells (HAEC) and coronary artery smooth muscle cells (HCASMC) in vitro, in terms of morphology, cell number, and phenotype. It was demonstrated that the polymer coatings can be tailored to enhance adhesion and growth of HAECs whilst suppressing that of HCASMCs. It is concluded that one of the polymer coatings (BTL 01015) shows potential as a stent coating to enhance re-endothelialization.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885328208099338

Reference26 articles.

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