Antimicrobial and antibiofilm activities of meropenem loaded-mesoporous silica nanoparticles against carbapenem-resistant Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Antimicrobial and antibiofilm activities of meropenem loaded-mesoporous silica nanoparticles against carbapenem-resistant Pseudomonas aeruginosa

Published:2021-03-15 Issue:4 Volume:36 Page:605-612
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Memar Mohammad Yousef¹,Yekani Mina²³,Ghanbari Hadi⁴,Nabizadeh Edris⁵,Vahed Sepideh Zununi⁶,Dizaj Solmaz Maleki⁷,Sharifi Simin⁷^ORCID

Affiliation:

1. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2. Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran

4. Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

6. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

7. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

The aims of the present study were the determination of antimicrobial and antibiofilm effects of meropenem-loaded mesoporous silica nanoparticles (MSNs) on carbapenem resistant Pseudomonas aeruginosa ( P. aeruginosa) and cytotoxicity properties in vitro. The meropenem-loaded MSNs had shown antibacterial and biofilm inhibitory activities on all isolates at different levels lower than MICs and BICs of meropenem. The viability of HC-04 cells treated with serial concentrations as MICs and BICs of meropenem-loaded MSNs was 92–100%. According to the obtained results, meropenem-loaded MSNs display the significant antibacterial and antibiofilm effects against carbapenem resistant and biofilm forming P. aeruginosa and low cell toxicity in vitro. Then, the prepared system can be an appropriate option for the delivery of carbapenem for further evaluation in vivo assays.

Funder

Tabriz University of Medical Sciences

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/08853282211003848

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