Titanium and Strontium-doped Phosphate Glasses as Vehicles for Strontium Ion Delivery to Cells-Reference-Cited by-同舟云学术

Titanium and Strontium-doped Phosphate Glasses as Vehicles for Strontium Ion Delivery to Cells

Published:2010-03-10 Issue:8 Volume:25 Page:877-893
ISSN:0885-3282
Container-title:Journal of Biomaterials Applications
language:en
Short-container-title:J Biomater Appl

Author:

Lakhkar Nilay¹,Abou Neel Ensanya A.²,Salih Vehid²,Knowles Jonathan Campbell²

Affiliation:

1. University College London, Eastman Dental Institute, London, UK,

2. University College London, Eastman Dental Institute, London, UK

Abstract

This study investigated the use of a Ti-containing quaternary phosphate glass system P2O5—Na2O—CaO—TiO 2 as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P2O5— 0.15Na2O—0.05TiO 2—(0.3 - x)CaO—xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885328210362125

Reference25 articles.

1. The processing, mechanical properties and bioactivity of strontium based glass polyalkenoate cements

2. Development of a strontium-containing hydroxyapatite bone cement

3. Ultrastructural study of mineralization of a strontium-containing hydroxyapatite (Sr-HA) cementin vivo

4. Mechanisms of Action and Therapeutic Potential of Strontium in Bone

5. Dose-dependent effects of strontium on osteoblast function and mineralization

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