Choice of Control in Clinical Trials—Issues and Implications of ICH-E10

Author:

Huitfeldt Bernhard,Danielson Linda,Ebbutt Alan,Schmidt Karsten

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Public Health, Environmental and Occupational Health,Drug guides,Pharmacology (nursing)

Reference6 articles.

1. International Conference on Harmonization. ICH topic E10—Choice of control group in clinical trials. Note for guidance on choice of control group in clinical trials. (CPMP/ICH/364/96). London, UK: European Agency for the Evaluation of Medicinal Products; July 27, 2000.

2. World Medical Association. Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects, revision of the 52nd WMA General Assembly. Edinburgh, Scotland: World Medical Association; October 2000.

3. Committee for Proprietary Medicinal Products. Points to Consider The choice of delta in non-inferiority studies.http://www.emea.eu.int/pdfs/human/ewp/215899en.pdf.

4. Temple R, Ellenberg S. Placebo-controlled trials and active-controlled trials in the evaluation of new treatments, Part 1: Ethical and scientific issues. Ann Intern Med., 2000;133:455–463.

5. Ellenberg S, Temple R. Placebo-controlled trials and active-controlled trials in the evaluation of new treatments, Part 2: Practical issues and specific cases issues. Ann Intern Med., 2000;133:464–470.

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