The Mathematical Basis of Multivariate Risk Screening: With Special Reference to Screening for Down's Syndrome Associated Pregnancy-Reference-Cited by-同舟云学术

The Mathematical Basis of Multivariate Risk Screening: With Special Reference to Screening for Down's Syndrome Associated Pregnancy

Published:1990-09 Issue:5 Volume:27 Page:452-458
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Reynolds T M¹,Penney M D¹

Affiliation:

1. Clinical Chemistry Department, Royal Gwent Hospital, Newport, Gwent, UK

Abstract

The underlying mathematical techniques behind the multivariate normal distribution are explained in principle and expanded in detail for up to three variables. The application of multivariate distributions to screening programs is described with particular reference to the calculation of risk ratios for the detection of Down's syndrome between 15 and 19 weeks of gestation.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456329002700506

Reference15 articles.

1. Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-fetoprotein level

2. Maternal serum α-fetoprotein, age, and Down syndrome risk

3. Screening for Fetal Down's Syndrome in Pregnancy by Measuring Maternal Serum Alpha-Fetoprotein Levels

4. Maternal serum screening for Down's syndrome in early pregnancy.

5. Improving Methods of Screening for Down's Syndrome

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