Comparison of Serum Osteocalcin with Total and Bone Specific Alkaline Phosphatase and Urinary Hydroxyproline: Creatinine Ratio in Patients with Paget's Disease of Bone-Reference-Cited by-同舟云学术

Comparison of Serum Osteocalcin with Total and Bone Specific Alkaline Phosphatase and Urinary Hydroxyproline: Creatinine Ratio in Patients with Paget's Disease of Bone

Published:1994-07 Issue:4 Volume:31 Page:327-330
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Kaddam I M S¹,Iqbal S J¹,Holland S¹,Wong M¹,Manning D¹

Affiliation:

1. Department of Chemical Pathology, Leicestershire District Pathology Service, Leicester Royal Infirmary, Leicester LE1 5WW, UK

Abstract

Osteocalcin or bone Gla protein (BGP) is secreted by osteoblasts, and its serum concentration is elevated in a number of conditions with high bone turnover. A comparison of serum osteocalcin with total (TALP) and bone specific alkaline phosphatase (BALP) and urinary hydroxyproline/creatinine (OHP/Cr ratio) was performed in 13 patients with active Paget's disease of bone. BGP did not correlate significantly with either BALP or TALP, but did show a significant correlation with OHP/Cr ratio ( r = 0·76; P<0·01). BGP does not appear to be as sensitive a marker as BALP or TALP in Paget's disease.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456329403100403

Reference12 articles.

1. Serum bone GLA-protein is not a sensitive marker of bone turnover in Paget's disease of bone

2. Concurrent Assays of Circulating Bone Gla-Protein and Bone Alkaline Phosphatase: Effects of Sex, Age, and Metabolic Bone Disease*

3. Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzymes in plasma.

4. Routine assay of total urinary hydroxyproline based on resin-catalysed hydrolysis

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