Effect of Heat Inactivation of HIV on Specific Serum Proteins and Tumour Markers

Author:

Gleeson Maree1,Herd Lynn1,Burns Christine1

Affiliation:

1. Hunter Immunology Unit, Royal Newcastle Hospital and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia

Abstract

The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56°C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for α-1-antitrypsin, β-2-microglobulin, IgE, fibrinogen, C***1-esterase inhibitor and CA125. Statistical, but not clinically significant, changes were observed for α-1-acid glycoprotein, C3, haptoglobin, IgA, IgG, IgM and transferrin. A significant decrease in the α-1 band was observed on protein electrophoresis.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

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