Development of a Radioimmunoassay for Pregnancy-Associated Plasma Protein A and Establishment of Normal Levels in the First Trimester of Pregnancy-Reference-Cited by-同舟云学术

Development of a Radioimmunoassay for Pregnancy-Associated Plasma Protein A and Establishment of Normal Levels in the First Trimester of Pregnancy

Published:1983-01 Issue:1 Volume:20 Page:26-30
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Anthony F¹,Masson G M¹,Wood P J²

Affiliation:

1. Department of Human Reproduction and Obstetrics, University of Southampton

2. Department of Chemical Pathology and Human Metabolism, University of Southampton

Abstract

An accelerated double antibody method has been developed for the radioimmunoassay of pregnancy-associated plasma protein A (PAPP-A) in serum. The workable range for the assay was 0·04–1·8 mg/l of serum. PAPP-A levels were determined in single serum samples from 110 women with prospective normal pregnancies of between 7 and 14 weeks' gestation. The level of pregnancy specific β1 glycoprotein (SP1) was also measured in these samples and normal ranges for PAPP-A and SP1 were constructed from the results obtained.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456328302000104

Reference19 articles.

1. Characterization of four human pregnancy-associated plasma proteins

2. Three Pregnancy-Associated Human Plasma Proteins: Purification, Monospecific Antisera and Immunological Identification

3. Placental Localization of Human Pregnancy—Associated Plasma Proteins

4. Tissue localization of pregnancy-associated plasma protein-A (PAPP-A) in normal placenta

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