Affiliation:
1. Neurological Clinic of the University of Cologne, D5 Cologne 41, Joseph-Stelzmann-Strasse 9, and Medical Clinic I, Cologne, West Germany
Abstract
The protein permeabilities of the blood-cerebrospinal-fluid barrier and the blood-urine barrier are compared. In both instances the permeation rates of proteins can be better correlated to hydrodynamic radii than to molecular weights. The decreasing clearance rates of ceruloplasmin, IgG, and IgA reflect the hydrodynamic heterogeneity of these three proteins, which have similar weights. The IgM clearance rate appears too high, possibly owing to monomer IgM, other IgM fragments, selective transport, or active immunity, so its inclusion is not recommended in clearance studies.
Subject
Clinical Biochemistry,General Medicine
Cited by
18 articles.
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