Affiliation:
1. Departments of Pediatrics and Pathology Children's Medical Center of Dallas and the University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA
Abstract
A convenient HPLC assay, which allows for the simultaneous measurement in extracellular fluids of 6-mercaptopurine and four of its metabolites, 6-thioguanine, 6-mercaptopurine riboside, 6-thioxanthine and 6-thiouric acid is described. Solid phase extraction allows for the clean isolation of analytes from plasma, urine or cerebrospinal fluid. The simultaneous determination of 6-mercaptopurine and some of its major metabolites in extracellular fluids may contribute to the monitoring of patient compliance, bioavailability, and individual variation in metabolism and absorption.
Subject
Clinical Biochemistry,General Medicine
Cited by
19 articles.
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