External Quality Assessment of Serum Enzyme Activity Assays and the Effect of Calibration on Interlaboratory Concordance

Author:

Bullock David G,Moss Donald W1,Whitehead Thomas P

Affiliation:

1. Department of Chemical Pathology, Royal Postgraduate Medical School, London W12 0HS

Abstract

The design and results of a UK external quality assessment scheme for six enzymes are described, from 21 surveys over a period of 7 years. Improvements in interlaboratory agreement and the adoption of reliable methods are documented. The potential of enzyme calibration materials in further improving numerical concordance between laboratories using different assay conditions, including temperature, is demonstrated and discussed.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Cited by 20 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Automated Enzyme Assays;Methods of Biochemical Analysis;2006-10-31

2. Identification of determinants of the between-operator variation of the total protein S antigen assay: a collaborative study of the Dutch Working Group on Haemostasis Laboratory Diagnosis;Scandinavian Journal of Clinical and Laboratory Investigation;2002-01

3. The quest for comparability: Calibration 2000;Accreditation and Quality Assurance;2000-09-05

4. Paradoxical behaviour of lyophilised commercial control materials for CK and CK-MB assays after reconstitution at either 4°C or 24°C;Clinica Chimica Acta;1997-05

5. Enzyme Standardization—the Way Forward?;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1997-01

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