Case report: Skin protective barrier cream interference in benzethonium chloride method for urine protein measurement in a 6-month-old girl-Reference-Cited by-同舟云学术

Case report: Skin protective barrier cream interference in benzethonium chloride method for urine protein measurement in a 6-month-old girl

Published:2023-11-26 Issue: Volume: Page:
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Özcan Ömer¹²^ORCID,van Wijk Joanna AE³,Bosch Annet M²⁴⁵,den Elzen Wendy PJ¹⁶⁷,Heijboer Annemieke C¹²⁴⁸,Fischer Johan C¹⁷^ORCID

Affiliation:

1. Department of Laboratory Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands

2. Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

3. Division of Pediatric Nephrology, Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, The Netherlands

4. Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

5. Division of Metabolic Diseases, Department of Pediatrics, Amsterdam UMC Location University of Amsterdam, Emma Children's Hospital, Amsterdam, The Netherlands

6. Amsterdam Public Health Research Institute, Amsterdam, Netherlands

7. Department of Laboratory Medicine, Laboratory Specialized Diagnostics & Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

8. Department of Laboratory Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

Abstract

This case report describes the positive interference of the commonly used skin protective barrier cream used together with urine collection bags on the benzethonium chloride method for urine protein measurements in a 6-month-old female baby, leading to falsely elevated results. The interference was identified by both artificially mixing urine samples with this cream and comparing the results obtained using the benzethonium chloride method with those obtained using the pyrogallol red method.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/00045632231218833

Reference6 articles.

1. Benzethonium chloride method for proteins adapted to centrifugal analysis.

2. New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine.

3. Positive and Negative Interference in the Benzethonium Chloride Method for Urine Protein

4. Homogentisic Acid Interference in the Measurement of Urinary Protein Using Benzethonium Chloride