Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment

Author:

Rad Babak1,Saleem Mohamed2,Grant Susan3,Florkowski Christopher3,Coates Penelope3,Gordon David1,Rankin Wayne2

Affiliation:

1. Microbiology & Infectious Diseases, SA Pathology and Flinders Medical Centre, Bedford Park, Australia

2. Division of Chemical Pathology, SA Pathology, Adelaide, Australia

3. Canterbury Health Laboratories, Christchurch, New Zealand

Abstract

We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

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