Measurement of Osmolality and Sodium Concentration in Heated-Cup Sweat Collections for the Investigation of Cystic Fibrosis

Author:

Kirk Jean M1,Adams A,Westwood A1,McCrae W M2

Affiliation:

1. Departments of Paediatric Biochemistry, Royal Hospital for Sick Children, Sciennes Road, Edinburgh, Scotland

2. Departments of Child Life and Health, Royal Hospital for Sick Children, Sciennes Road, Edinburgh, Scotland

Abstract

A new system (Wescor) for sweat collection and analysis was examined with respect to its suitability for the investigation of children suspected to have cystic fibrosis. The effects of iontophoresis current, sweat collection time, sweat storage and analysis were examined, and as a result the technique was modified to allow collection and storage of sufficient sweat for sodium and potassium as well as osmolality assays in 10–20 minutes. The small electrodes and speed of the procedure make it practical for use with small children, with a reproducibility of 13–24 % (coefficient of variation for whole procedure).

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. ABNORMALLY HIGH SWEAT OSMOLALITY IN CHILDREN WITH DOWN'S SYNDROME;Journal of Intellectual Disability Research;2008-06-28

2. Current concepts: Osmosis, osmometry, and osmoregulation;Postgraduate Medical Journal;1999-02-01

3. The Assessment of Gastrointestinal Function;Scientific Foundations of Biochemistry in Clinical Practice;1994

4. Variation of Sweat Sodium and Chloride with Age in Cystic Fibrosis and Normal Populations: Further Investigations in Equivocal Cases;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1992-03

5. Development and Evaluation of the Simultaneous Determination of Sweat Sodium and Chloride by Ion-Selective Electrodes;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1991-03

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