A Non-Extraction HPLC Method for the Simultaneous Determination of Serum Paracetamol and Salicylate-Reference-Cited by-同舟云学术

A Non-Extraction HPLC Method for the Simultaneous Determination of Serum Paracetamol and Salicylate

Published:1988-11 Issue:6 Volume:25 Page:661-667
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Dawson C M¹,Wang T W M¹,Rainbow S J¹,Tickner T R¹

Affiliation:

1. Department of Chemical Pathology, Norfolk & Norwich Hospital, Brunswick Road, Norwich NR1 3SR, UK

Abstract

A direct injection HPLC method for the sumultaneous measurement of serum paracetamol and salicylate is described using a Pinkerton internal surface reversed-phase column with benzoic acid as internal standard. The method is linear to at least 1000 mg/L for both drugs and shows good precision at levels of 62–500 mg/L. None of the drugs tested for interference affected the quantitation of either drug. In patient samples, the values obtained with this method correlated well with those from enzymatic paracetamol and Trinder salicylate methods.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456328802500611

Reference38 articles.

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