A Study of the Hypouricaemic Effect of Tiaprofenic Acid-Reference-Cited by-同舟云学术

A Study of the Hypouricaemic Effect of Tiaprofenic Acid

Published:1988-11 Issue:6 Volume:25 Page:595-600
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

Lyfar Vivienne¹,Fernandes L²,Thornton Elizabeth³,Cook J G H¹

Affiliation:

1. Department of Biochemistry, Royal Sussex County Hospital, Brighton BN2 5BE

2. Department of Rheumatology, Royal Sussex County Hospital, Brighton BN2 5BE

3. Roussel Laboratories, Middx UB9 5HP, UK

Abstract

Tiaprofenic acid is a non-steroidal anti-inflammatory drug which also has hypouriceamic effect. Studies involving 10 healthy volunteers were designed to investigate the mode of this effect. We postulate that the site of action of tiaprofenic acid is at the cell membrane, the mechanism being an interference with the transport of uric acid from intra- to extra-cellular fluid thus limiting its passage into the plasma. The same mechanism acting on renal tubular cells impedes reabsorption thereby increasing uric acid clearance.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456328802500601

Reference10 articles.

1. Keppel G. Design and Analysis. New Jersey: Prentice-Hall Inc, 1982; 155.

2. An Analytical System for Rapid Separation of Tissue Nucleotides at Low Pressures on Conventional Anion Exchangers

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