The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease

Author:

Teraura Hiroyuki12,Kotani Kazuhiko1,Minami Takaomi3,Takeshima Taro1,Shimooki Osamu12,Kajii Eiji1

Affiliation:

1. Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan

2. Department of Medicine, Iwate Prefectural Senmaya Hospital, Iwate, Japan

3. Department of Pediatrics, Jichi Medical University, Tochigi, Japan

Abstract

Kawasaki disease is a febrile disease of childhood that is associated with increased inflammatory cytokines and immunoregulatory abnormalities. While the serum concentrations of soluble IL-2 receptor can change under such pathologies, the relevance of the soluble IL-2 receptor concentration in patients with Kawasaki disease has not been specified. We aimed to summarize the existing studies that reported the soluble IL-2 receptor concentrations in patients with Kawasaki disease. Original articles that were published up to July 2016 were collected using a PubMed/Medline-based search engine. A total of nine articles that reported the serum soluble IL-2 receptor concentrations in acute-phase Kawasaki disease were eligible. All of the articles described a high soluble IL-2 receptor concentration in patients with Kawasaki disease relative to the level of controls or the reference range. Two of five articles on patients with coronary artery aneurysms described a significantly higher soluble IL-2 receptor concentration in patients with coronary artery aneurysms than patients without. Two articles on patients with intravenous immunoglobulin therapy described a significant decrease of the soluble IL-2 receptor concentration after the therapy. Accordingly, the serum soluble IL-2 receptor can be a potent marker of disease activity and therapeutic effects in patients with Kawasaki disease; further studies are thus warranted for its use in the clinical setting.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

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