ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study-Reference-Cited by-同舟云学术

ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study

Published:2017-08-04 Issue:7 Volume:52 Page:680-689
ISSN:0004-8674
Container-title:Australian & New Zealand Journal of Psychiatry
language:en
Short-container-title:Aust N Z J Psychiatry

Author:

Lee Sheng-Yu¹²³⁴⁵,Wang Tzu-Yun⁵,Chen Shiou-Lan⁵⁶,Chang Yun-Hsuan⁵⁷,Chen Po-See⁵⁸,Huang San-Yuan⁹,Tzeng Nian-Sheng⁹¹⁰,Wang Liang-Jen¹¹¹,Lee I-Hui⁵,Chen Kao-Chin⁵,Yang Yen Kuang⁵¹²,Yang Yi-Hsin¹³,Chen Cheng-Sheng¹²¹⁴,Lu Ru-Band⁵⁸¹⁵¹⁶

Affiliation:

1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

2. Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

3. Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

4. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan

5. Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan

6. Lipid Science and Aging Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

7. Department of Psychology, Asia University, Taichung, Taiwan

8. Addiction Research Center, National Cheng Kung University, Tainan, Taiwan

9. Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

10. Student Counseling Center, National Defense Medical Center, Taipei, Taiwan

11. Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

12. Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan

13. School of Pharmacy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

14. Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

15. Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

16. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan

Abstract

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

Funder

National Science Council

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0004867417720517

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