Prior Neurologic Illness and the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (Silent)

Author:

Adityanjee 1,Balaraju K.B.1,Ahuja G.K.1

Affiliation:

1. Department of Psychiatry and Department of Neurology, All India Institute of Medical Sciences, New Delhi, India

Abstract

Prior neurologic illness or CNS insult of any kind is known to increase the vulnerability to neurotoxicity of lithium. In this event the occurrence of neurotoxicity does not correlate with serum lithium levels. The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode. The authors review the literature on this aspect and highlight the dangers of starting lithium treatment in patients with neurologic impairment.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Review of Lithium Effects on Brain and Blood;Cell Transplantation;2009-09

2. Neuropsychiatric Sequelae of Neuroleptic Malignant Syndrome;Clinical Neuropharmacology;2005-07

3. The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity;Clinical Neuropharmacology;2005-01

4. Lithium Toxicity;Emergency Medicine Clinics of North America;1994-05

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