A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable

Author:

English Coralie12ORCID,Simpson Dawn B12ORCID,Billinger Sandra A3ORCID,Churilov Leonid4,Coupland Kirsten G25,Drummond Avril6,Kuppuswamy Annapoorna7ORCID,Kutlubaev Mansur A8ORCID,Lerdal Anners910ORCID,Mahmood Amreen11,Moseley G Lorimer12,Pittman Quentin J13,Riley Ellyn A14ORCID,Sutherland Brad A15ORCID,Wong Connie HY16ORCID,Corbett Dale17,Mead Gillian18ORCID

Affiliation:

1. School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia

2. Heart and Stroke Program, Hunter Medical Research Institute, Newcastle, NSW, Australia

3. Department of Neurology, University of Kansas Medical Centre, University of Kansas Alzheimer’s Disease Research Centre, Kansas City, KS, USA

4. Department of Medicine (RMH), University of Melbourne, Heidelberg, VIC, Australia

5. School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia

6. School of Health Sciences, University of Nottingham, Nottingham, UK

7. Queen Square Institute of Neurology, University College London, London, UK

8. Department of Neurology, Bashkir State Medical University, Ufa, Russia

9. Department of Interdisciplinary Health Sciences, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway

10. Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway

11. Faculty of Health, Health and Education, Manchester Metropolitan University, Manchester, UK

12. IIMPACT in Health, University of South Australia, Adelaide, SA, Australia

13. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

14. Department of Communication Sciences and Disorders, Syracuse University, Syracuse, NY, USA

15. Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia

16. Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia

17. Department of Cellular and Molecular Medicine, University of Ottawa Roger Guindon Hall, Ottawa, ON, Canada

18. Ageing and Health, Usher Institute, University of Edinburgh, Edinburgh, UK

Abstract

Rationale: Fatigue affects almost half of all people living with stroke. Stroke survivors rank understanding fatigue and how to reduce it as one of the highest research priorities. Methods: We convened an interdisciplinary, international group of clinical and pre-clinical researchers and lived experience experts. We identified four priority areas: (1) best measurement tools for research, (2) clinical identification of fatigue and potentially modifiable causes, (3) promising interventions and recommendations for future trials, and (4) possible biological mechanisms of fatigue. Cross-cutting themes were aphasia and the voice of people with lived experience. Working parties were formed and structured consensus building processes were followed. Results: We present 20 recommendations covering outcome measures for research, development, and testing of new interventions and priority areas for future research on the biology of post-stroke fatigue. We developed and recommend the use of the Stroke Fatigue Clinical Assessment Tool. Conclusions: By synthesizing current knowledge in post-stroke fatigue across clinical and pre-clinical fields, our work provides a roadmap for future research into post-stroke fatigue.

Funder

unrestricted educational grants provided by Ipsen Pharma and Moleac

NHMRC Centre of Research Excellence to Accelerate Stroke Trial Innovation and Translation

Canadian Partnership for Stroke Recovery

Publisher

SAGE Publications

Subject

Neurology,Neurology (clinical)

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