A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Author:

Bernhardt Julie1,Hayward Kathryn S1ORCID,Dancause Numa2,Lannin Natasha A3ORCID,Ward Nick S4,Nudo Randolph J5,Farrin Amanda6,Churilov Leonid7,Boyd Lara A8ORCID,Jones Theresa A9,Carmichael S Thomas10,Corbett Dale11,Cramer Steven C12

Affiliation:

1. Stroke Theme and NHRMC CRE in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

2. Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada

3. Department of Clinical Neuroscience, Central Clinical School, Monash University; Alfred Health, Melbourne, Australia

4. Department of Clinical and Motor Neuroscience, UCL Queen Square Institute of Neurology, London, UK

5. Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA

6. Leeds Institute of Clinical Trial Research, University of Leeds, Leeds, UK

7. Melbourne Medical School, University of Melbourne, Melbourne, Australia

8. Department of Physical Therapy & Centre for Brain Health, University of British Columbia, Vancouver, Canada

9. Psychology Department and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA

10. Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

11. Cellular & Molecular Medicine and Canadian Partnership for Stroke Recovery, University of Ottawa, Ottawa, Canada

12. Department of Neurology, David Geffen School of Medicine at UCLA; California Rehabilitation Institute, Los Angeles, CA, USA

Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Publisher

SAGE Publications

Subject

Neurology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3