Validity and Normative Data for the Biber Figure Learning Test: A Visual Supraspan Memory Measure-Reference-Cited by-同舟云学术

Validity and Normative Data for the Biber Figure Learning Test: A Visual Supraspan Memory Measure

Published:2018-05-29 Issue:6 Volume:27 Page:1320-1334
ISSN:1073-1911
Container-title:Assessment
language:en
Short-container-title:Assessment

Author:

Gifford Katherine A.¹,Liu Dandan¹,Neal Jacquelyn E.¹,Acosta Lealani Mae Y.¹,Bell Susan P.¹,Wiggins Margaret E.²,Wisniewski Kristi M.³,Godfrey Mary⁴,Logan Laura A.¹,Hohman Timothy J.¹,Pechman Kimberly R.¹,Libon David J.⁵,Blennow Kaj⁶⁷,Zetterberg Henrik⁶⁷⁸⁹,Jefferson Angela L.¹

Affiliation:

1. Vanderbilt University Medical Center, Nashville, TN, USA

2. University of Florida, Gainesville, FL, USA

3. University of Southern California, Los Angeles, CA, USA

4. Drexel University, Philadelphia, PA, USA

5. Rowan University, Stratford, NJ, USA

6. University of Gothenburg, Mölndal, Sweden

7. Sahlgrenska University Hospital, Mölndal, Sweden

8. UCL Institute of Neurology, Queen Square, London, UK

9. UK Dementia Research Institute at UCL, London, UK

Abstract

The Biber Figure Learning Test (BFLT), a visuospatial serial figure learning test, was evaluated for biological correlates and psychometric properties, and normative data were generated. Nondemented individuals ( n = 332, 73 ± 7, 41% female) from the Vanderbilt Memory & Aging Project completed a comprehensive neuropsychological protocol. Adjusted regression models related BFLT indices to structural brain magnetic resonance imaging and cerebrospinal fluid (CSF) markers of brain health. Regression-based normative data were generated. Lower BFLT performances (Total Learning, Delayed Recall, Recognition) related to smaller medial temporal lobe volumes and higher CSF tau concentrations but not CSF amyloid. BFLT indices were most strongly correlated with other measures of verbal and nonverbal memory and visuospatial skills. The BFLT provides a comprehensive assessment of all aspects of visuospatial learning and memory and is sensitive to biomarkers of unhealthy brain aging. Enhanced normative data enriches the clinical utility of this visual serial figure learning test for use with older adults.

Funder

Swedish Research Council

National Institutes of Health

Swedish Alzheimer’s Association

Torsten Söderberg Foundation, Stockholm, Sweden

National Institute on Aging

National Institute of Neurological Disorders and Stroke

National Heart, Lung, and Blood Institute

Eisenstein Women’s Heart Fund

Alzheimer’s Association

Vanderbilt’s High-Performance Computer Cluster for Biomedical Research

Vanderbilt Institute for Clinical & Translational Research