Psychological Factors and Pet Measured Glucose Metabolism in Olivopontocerebellar Atrophy

Abstract

We compared 29 olivopontocerebellar atrophy (OPCA) patients on psychiatric rating scales, cognitive tests, and positron emission tomography to 12 normal volunteers with similar age and sex distributions. The patients were generally comparable to normals in cognitive function, but poorer on psychomotor tasks. They had significantly different scores on formal self-report scales than the normals, indicating a greater degree of self-complaint. Analyses of the components of self-complaint suggested that illness-related concerns accounted for most of the differences between the groups. The magnitude of self-complaint was significantly and specifically correlated with the level of glucose metabolism in the frontal cerebral cortex of OPCA patients. These results may be attributed to a combination of biological and experiential factors. The level of patient complaint may be influenced by organic brain dysfunction reflected in metabolism and emotional disturbance, whereas the content of complaint may be specific to the individual's situational experience.