Prevalence and Associated Clinical Characteristics of Walking-Related Motor, Cognitive, and Fatigability in Progressive Multiple Sclerosis: Baseline Results From the CogEx Study-Reference-Cited by-同舟云学术

Prevalence and Associated Clinical Characteristics of Walking-Related Motor, Cognitive, and Fatigability in Progressive Multiple Sclerosis: Baseline Results From the CogEx Study

Published:2024-03-01 Issue:5 Volume:38 Page:327-338
ISSN:1545-9683
Container-title:Neurorehabilitation and Neural Repair
language:en
Short-container-title:Neurorehabil Neural Repair

Author:

Ramari Cintia¹²^ORCID,D’hooge Mieke¹³,Dalgas Ulrik⁴^ORCID,Feinstein Anthony⁵,Amato Maria Pia⁶⁷,Brichetto Giampaolo⁸⁹,Chataway Jeremy¹⁰¹¹,Chiaravalloti Nancy D.¹²¹³^ORCID,Cutter Gary R¹⁴,DeLuca John¹²¹³,Farrell Rachel¹⁰¹¹,Filippi Massimo¹⁵¹⁶¹⁷¹⁸¹⁹^ORCID,Freeman Jennifer²⁰,Inglese Matilde²¹²²,Meza Cecilia⁵,Motl Robert W.²³,Rocca Maria A¹⁵¹⁶^ORCID,Sandroff Brian M.¹²¹³^ORCID,Salter Amber²⁴^ORCID,Kos Daphne³,Feys Peter¹²^ORCID

Affiliation:

1. REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Limburg, Belgium

2. UMSC University MS Center Hasselt Pelt, Hasselt Pelt, Belgium

3. National MS Center, Melsbroek, Belgium

4. Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark

5. Department of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada

6. Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy

7. IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy

8. Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy

9. AISM Rehabilitation Service, Italian Multiple Sclerosis Society, Genoa, Italy

10. Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK

11. National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK

12. Kessler Foundation, East Hanover, NJ, USA

13. Department of Physical Medicine & Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA

14. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

15. Neuroimaging Research Unit, Institute of Experimental Neurology, IRCSS San Raffaele Scientific Institute, Milan, Italy

16. Neurology Unit, IRCSS San Raffaele Scientific Institute, Milan, Italy

17. Neurorehabilitation Unit, IRCSS San Raffaele Scientific Institute, Milan, Italy

18. Neurophysiology Service, IRCSS San Raffaele Scientific Institute, Milan, Italy

19. Vita-Salute San Raffaele University, Milan, Italy

20. Faculty of Health, School of Health Professions, University of Plymouth, Devon, UK

21. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy

22. IRCCS Ospedale Policlinico San Martino, Genoa, Italy

23. Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA

24. Department of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, TX, USA

Abstract

Background: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task. Objective: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients. Methods: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and CF using the SDMT (scores from the last 30 seconds compared to the first 30 seconds). Additional measures were: cognitive assessment—Brief International Cognitive Assessment for multiple sclerosis (MS), cardiorespiratory fitness, 6-minute walk, physical activity, depressive symptoms, perceived fatigue—Modified Fatigue Impact Scale (MFIS), MS impact—MSIS-29, and walking ability. Results: Of 298 participants, 153 (51%) presented WF (DWI = −28.9 ± 22.1%) and 196 (66%) presented CF (−29.7 ± 15%). Clinical characteristics (EDSS, disease duration, and use of assistive device) were worse in patients with versus without WF. They also presented worse scores on MSIS-29 physical, MFIS total and physical and reduced physical capacity. CF patients scored better in the MSIS-29 physical and MFIS psychosocial, compared to non-CF group. Magnitude of CF and WF were not related. Conclusions: Half of the cognitively-impaired PMS population presented WF which was associated with higher disability, physical functions, and fatigue. There was a high prevalence of CF but without strong associations with clinical, cognitive, and physical functions. Trial Registration Number: The “CogEx-study,” www.clinicaltrial.gov identifier number: NCT03679468.

Funder

Multiple Sclerosis Society of Canada

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/15459683241236161

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