Generalized Pustular Psoriasis Induced by Infliximab in a Patient With Inflammatory Bowel Disease

Abstract

The incidence of anti–tumour necrosis factor (TNF)–induced psoriasiform eruptions has ranged in the literature between 0.5% and 10.9% of patients with inflammatory bowel disease (IBD). The morphology of the rash varies, with plaque psoriasis being the most common form. Generalized pustular eruption is reported in 10.2% of cases of anti–TNF-induced psoriasis. We are reporting a unique case of anti–TNF-associated psoriasiform eruption due to the severity of the rash presenting as a generalized pustular eruption in association with plaque psoriasiform rash requiring systemic therapy.