Pediatric Lip Adhesion Following Bullous Erythema Multiforme and Review of Similar Oral Complications

Abstract

Background: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. Objective: We report a case of lip adhesion as a complication of EM in a child who required corrective surgery and review similar oral commissure complications. Methods: We completed a review of the literature for similar cases using PubMed and Medline. Conclusions and Relevance: We present the youngest report of lip adhesion due to striking mucositis related to EM. Sequelae of erythema multiforme can be significant, in our case requiring surgery. Meticulous oral hygiene should be encouraged when mucosal lesions are identified.